Woman was screened and diagnosed with Stage IIIB NSCLC (type not given) within a week at age 41 with mets to the ribs and spine. Diagnosis was confirmed by needle biopsy, bronchoscopy, mediastinoscopy). Symptoms were shortness of breath, persistent cough, pleurisy and pain in back and left arm. She underwent a lobectomy followed 9 months later by radiation and chemotherapy (cisplatin and VP-16) and currently NED. She was a current smoker with an average 38 pack year history and additional exposure to second hand smoke at home as a child and an adult, and a history of asthma and pneumonia as an infant, multiple incidences of bronchitis, and emphysema at 37. While there is no family history of lung cancer, ten close maternal and paternal relatives had various cancers including bladder and throat.